What Is Diprolene Cream
DIPROLENE AF Cream is a prescription corticosteroid medicine used on the skin for the relief of redness, swelling, heat, pain and itching, caused by certain skin problems in people 13 years of age and older.
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Which ointment is best for itching in private parts female?
Clotrimazole Vaginal Cream will cure most vaginal yeast infections. Clotrimazole Vaginal Cream can kill the yeast that cause vaginal yeast infections and can relieve the associated itching and burning.
Carcinogenesis Mutagenesis Impairment Of Fertility
Long-term animal studies have not been performed to evaluate the carcinogenic potential of the combination of clotrimazole and betamethasone dipropionate or either component individually.
Betamethasone was negative in the bacterial mutagenicity assay and in the mammalian cell mutagenicity assay . It was positive in thein vitro human lymphocyte chromosome aberration assay, and equivocal in the in vivo mouse bone marrow micronucleus assay.
Reproductive studies with betamethasone dipropionate conducted in rabbits at doses of 1.0 mg/kg/day by the intramuscular route and in mice up to 33 mg/kg/day by the intramuscular route indicated no impairment of fertility except for dose-related increases in fetal resorption rates in both species.
In a combined study of the effects of clotrimazole on fertility, embryofetal development, and postnatal development, male and female rats were dosed orally with dose levels of 5, 10, 25, or 50 mg/kg/day from 10 weeks prior to mating until 4 weeks postpartum. No adverse effects on the duration of estrous cycle, fertility, or duration of pregnancy were noted.
What Should I Discuss With My Healthcare Provider Before Using Betamethasone And Clotrimazole Topical
You may not be able to use this medicine if you are allergic to betamethasone or clotrimazole, or if you have ever had an allergic reaction to:
- other steroid medicines or
- other antifungal medicines .
Tell your doctor if you have ever had:
- a skin reaction to any steroid medicine
- cataract or glaucoma
- liver disease or
- an adrenal gland disorder.
Steroid medicines can increase the glucose levels in your blood or urine. Tell your doctor if you have diabetes.
Using highly potent steroid medicine during pregnancy may increase the risk of low birthweight in the newborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. If you apply betamethasone and clotrimazole to your chest, avoid areas that may come into contact with the baby’s mouth.
If you are pregnant or breastfeeding, apply this medicine to the smallest skin area and for the shortest amount of time possible to treat your condition.
This medicine is not approved for use by anyone younger than 17 years old. Children can absorb larger amounts of this medicine through the skin and may be more likely to have side effects.
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Clotrimazole And Betamethasone Dipropionate Cream Dosage
The dosage of this medication will largely depend on the type of infection your have got. For example, if you are infected with jock itch or ringworm , you will need to apply this cream for two weeks.
In case, you have got athletes foot, you will have to apply it for four weeks. Please make sure not to use 45 grams of this cream per week unless directed by your doctor.
How Should I Use This Medication
This cream is for external use only. Do not take by mouth. Follow the directions on the prescription label. Wash your hands before and after use. If treating hand or nail infections, wash hands before use only. Apply a thin layer of cream to the affected area and rub in gently. Do not cover or wrap the treated area with an airtight bandage . Use the cream for the full course of treatment prescribed, even if you think the condition is getting better. Use the medicine at regular intervals. Do not use more often than directed. Do not use on healthy skin or over large areas of skin. Do not use this medicine for any condition other than the one for which it was prescribed. When applying to the groin area, apply a small amount and do not use for longer than 2 weeks unless directed to by your doctor or health care professional. Do not get this cream in your eyes. If you do, rinse out with plenty of cool tap water.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 17 years for selected conditions, precautions do apply.
Patients over 65 years old may have a stronger reaction and need a smaller dose.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Drug Content Ph And Viscosity
The evaluated formulations were the two combination gel formulations as well as Lignocaine® 5% gel that contains 5% LDH and Betaderm® cream with 0.1% BMV as two marketing products of LDH and BMV, respectively, for comparison. One gram of each gel was vortexed with 25mL methanol for 5min and then sonicated for 15min to extract the drugs. The mixture was centrifuged for 15min. The supernatant was filtered through 0.2µm Millipore filter and suitably diluted to be assayed utilizing the HPLC assay method previously illustrated. PH measurement was accomplished using a calibrated digital pH meter in triplicate and the average values were calculated. The viscosity was estimated using a calibrated cone and plate rotary viscometer . The temperature was maintained at 37±0.5°C. One gram of each formulation was placed on the plate and the torque value was determined to maintain the speed at 256rpm. Viscosity was calculated using the equation , where :viscosity in , G:instrumental factor , S: torque and N: speed .
Indications And Usage For Clotrimazole Betamethasone Cream
Clotrimazole and betamethasone dipropionate cream is a combination of an azole antifungal and corticosteroid and is indicated for the topical treatment of symptomatic inflammatory tinea pedis, tinea cruris, and tinea corporis due to Epidermophyton floccosum, Trichophyton mentagrophytes, and Trichophyton rubrum in patients 17 years and older.
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Embarrassing Ailment Thats Tough To Cure
Q: What can I do about persistent, intermittent rectal itch? I keep the area clean and dry and have tried numerous over-the-counter anti-itch medications, which seem to work for a short time before becoming ineffective. My primary care physician gave me an anti-fungal prescription , which my dermatologist said was unwarranted. Your suggestions?
Other factors can lead to pruritus ani as well, with fungal infections accounting for 15 percent of episodes. People with diabetes, those who are taking medications that suppress the immune system and those who have used multiple courses of antibiotics are at increased risk of this type of infection.
ASK THE DOCTORS is written by Robert Ashley, M.D., Eve Glazier, M.D., and Elizabeth Ko, M.D. Send questions to askthedoctors@
mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095.
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What Should I Know About Storage And Disposal Of This Medication
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture .
It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.
Topical Creams And Ointments
In addition, these products usually contain a small amount of one or more active ingredients. The active ingredients include an antiseptic , a local anaesthetic agent that numbs the area, corticosteroids that reduce inflammation, and vasoconstrictors that make the blood vessels in the area become smaller, which may reduce swelling and help dry the area.
Products that contain a corticosteroid with a local anaesthetic include Proctosedyl®, Rectinol HC®, Scheriproct®, Ultraproct®. Others contain a vasoconstrictor with local anaesthetic .
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Can Clotrimazole And Betamethasone Dipropionate Cream Be Used For Hemorrhoids
The shrinking of the internal hemorrhoids allows for the rectum to close more efficiently. We will use topical Clotrimazole and 2% hydrocortisone, a prescription anti-fungal cream to help treat the itching, rash, and infection until the hemorrhoid banding can be completed.
Can you put clotrimazole and betamethasone?
Clotrimazole and betamethasone topical combination is used to treat fungus infections. Clotrimazole works by killing the fungus or preventing its growth. Betamethasone, a corticosteroid , is used to help relieve redness, swelling, itching, and other discomfort of fungus infections.
Can clotrimazole and betamethasone dipropionate cream be used on the face?
Do not use betamethasone and clotrimazole cream on the face or underarms. This medicine may raise the chance of cataracts or glaucoma.
Before Using Topical Clotrimazole
- tell your doctor and pharmacist if you are allergic to clotrimazole, any other medications, or any of the ingredients in clotrimazole cream or liquid. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using clotrimazole, call your doctor.
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How To Use Clotrimazole And Betamethasone Dipropionate Cream
Always try to read the information given on the leaflet provided along with the medication. If in any doubt, always consult with your doctor or pharmacist. Also remember to shake the bottle before use.
Please keep in mind that the above medication is only meant for external use. And so, the cream should be applied on skin. If your doctor has prescribed it, then place a thin layer of this medication over your skin and gently rub.
In case, you have got this medication in any of these areas, simply flush it off with water.
Are There Any Other Precautions Or Warnings For This Medication
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Inform all health professionals involved in your care that you have been using corticosteroids.
Eyes: Do not use this medication in or around the eyes. Wash your hands and do not touch your eyes after applying this medication. Absorption of this medication around the eyes can increase the risks for developing cataracts or glaucoma. If you experience blurred vision or any other changes to your eyesight, contact your doctor as soon as possible.
Medical conditions: If you have stasis dermatitis and other skin conditions with reduced blood circulation, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Thinning of skin: Prolonged use of topical corticosteroid products may produce thinning of the skin and tissues under it. If you notice this, call your doctor.
Breast-feeding: It is not known if this medication passes into breast milk. If you are a breast-feeding mother and are using this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
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Conditions To Use Clotrimazole And Betamethasone Dipropionate Cream Usp:
Your skin is sensitiveyour concern about it. We find several conditions. If these conditions appear, start these tubes but with dermatologist recommendations.
- Your skin has large burned or damaged areas.
- Your skin is becoming thin.
- You are suffering from peripheral vascular disease.
- You are feeling low circulation under the skin.
- Your skin effected due to any unusual side effects.
Clotrimazole And Betamethasone Dipropionate Hemorrhoids
Generic Name Betamethasone DrugBank Accession Number DB00443 Background. Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. 11 It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including.
Betamethasone is highly potent steroid that reduces itching, swelling, and redness of the skin. Clotrimazole is an antifungal medication that fights infections caused by fungus. Betamethasone and clotrimazole topical is a combination medicine used to treat fungal skin infections such as athlete’s foot, jock itch, and ringworm.
Find patient medical information for clotrimazole-betamethasone topical on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
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Clotrimazole is an odorless, white crystalline powder, insoluble in water and soluble in ethanol. Betamethasone dipropionate has the chemical name 9-fluoro-11(,17,21-trihydroxy-16(-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate, with the empirical formula C 28 H 37 FO 7, a molecular weight of 504. 59, and the following structural formula:
Cipla Limited View all information regarding the medicines that are manufactured by Cipla Limited including its generic drug name, trade name, how to use, the price, and its composition. Aceclofenac is a.
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How To Use Clotrimazole
Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
If you are using the lotion form of this medication, shake the bottle well before each use.
Use this medication on the skin only. Clean and thoroughly dry the area to be treated. Apply a thin layer of the medication to the affected area and gently rub in, usually twice daily or as directed by your doctor. Wash your hands after using unless you are using this medication to treat the hands. Do not wrap, cover, or bandage the area unless directed to do so by your doctor. Wear loose-fitting clothes after applying the medication to the groin area.
Do not apply the medication in the eyes, nose, mouth, or inside the . If you do get the medication in those areas, flush with plenty of water.
The dosage and length of treatment depends on the type of infection being treated. Ringworm or jock itch is usually treated for 2 weeks, and athlete’s foot is usually treated for 4 weeks. Do not use more than 45 grams of the cream or 45 milliliters of the lotion per week unless directed and closely monitored by your doctor.
Do not apply more often or use longer than prescribed. This may increase the risk of side effects.
Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.
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No, clotrimazole and betamethasone cream is not meant to apply on hemorrhoids& will not provide any relief from burning itch and pain. Following is recommended for you now: Please apply cream called preparation H. You can. Answer : Liang-Hai Sie answered this question for you. Naturally you can eliminate hemorrhoids by eating a more high fiber diet. Immediately start eating non-acidic fruits and vegetables either steamed or in soups. Stews are good too. By excluding acidic foods while you have this cond.
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In Vitro Release Studies
In vitro release of NIF, LDH, and BMV from the formulations was studied using a specially designed diffusion cell . Cellophane membrane was soaked before the experiment in the release medium of phosphate buffer pH 7.4 with 0.5% sodium lauryl sulfate. The membrane was stretched over the open end of 3cm diameter glass tube and was made watertight by a rubber band. Two grams of each formulation were equally spread on the cellophane membrane. The donor cells were immersed in 250mL beaker containing 100mL release medium maintained at 37±0.5°C in a thermostatically controlled shaking water bath . The donor cells height was adjusted so that the membrane was just below the release medium surface. The cells were shaken at 25 strokes per min. One-milliliter samples were withdrawn from the receiver compartment at 0.25, 0.5, 1, 2, 3, 4, 5, 6, 7, and 8h and replaced by an equal volume of fresh medium at the same temperature.
The amounts of drugs permeated per 1cm2 were determined using the previously illustrated HPLC method to be plotted against time. The intercept and slope of the linear portion of the plots were derived by linear regression. The steady-state permeation flux for each drug in each formula was calculated as the slope divided by the membrane surface area .
Where Jss is the permeation flux at steady-state , A is the area of cellophane membrane , and ss is the amount of drug permeated at steady state per unit time .